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More Great Information on Monitor Clinical:
Seeing what’s inside a tumor (MIT)
Gliomas, the most common types of brain tumor, are also among the deadliest
cancers: Their mortality rate is nearly 100 percent, in part because there are
very few treatments available.
A team of researchers from MIT, Harvard University, Massachusetts General
Hospital (MGH) and Agios Pharmaceuticals has now developed a way to identify a
particular subset of brain tumors, which may help doctors choose treatments
and create new drugs that target the disease’s underlying genetic mutation.
Scientists have known for several years that many brain tumors involve a
mutation in the gene for an enzyme called isocitrate dehydrogenase (IDH). This
enzyme is involved in cell metabolism — the process of breaking down sugar
molecules to extract energy from them. IDH mutations are found in up to 86
percent of low-grade gliomas, which have a better prognosis than high-grade
gliomas, also called glioblastomas. Patients with low-grade gliomas can
survive for years, though the tumors almost always prove fatal.
Several pharmaceutical companies are now pursuing drugs that target IDH, in
hopes of halting tumor growth. Some of those drugs may enter clinical trials
within the year, says Matthew Vander Heiden, a member of the David H. Koch
Institute for Integrative ...
Tags: clinical, health, healthcare, monitor, monitor clinical, monitor clinical investigations, monitor clinical site, monitor clinical study, monitor clinical trials, temp_sony_monitor




































































































